Obesity

Curcumin and Obesity

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Endocrinology. First published ahead of print April 10, 2008 as doi:10.1210/en.

2008-0262

Dietary Curcumin Significantly Improves Obesity-Associated

Inflammation and Diabetes

in Mouse Models of Diabesity

Stuart P. Weisberg1, Rudolph Leibel1, and Drew V. Tortoriello1, 2

ABSTRACT

Obesity is a major risk factor for the development of type 2 diabetes, and both

conditions

are now recognized to possess significant inflammatory

components underlying their

pathophysiologies. We tested the hypothesis that

the plant polyphenolic compound curcumin,

which is known to exert potent

anti-inflammatory and anti-oxidant effects, would ameliorate

diabetes and

inflammation in murine models of insulin-resistant obesity. We found that

dietary

curcumin admixture ameliorated diabetes in high-fat diet induced

obese (DIO) and leptindeficien

ob/ob male C57BL/6J mice as determined by

glucose and insulin tolerance testing and

hemoglobin A1c percentages.

Curcumin treatment also significantly reduced macrophage

infiltration of white

adipose tissue, increased adipose tissue adiponectin production, and

decreased hepatic nuclear NF-κB activity, hepatomegaly, and markers of

hepatic inflammation.

We therefore conclude that orally ingested curcumin

reverses many of the inflammatory and

metabolic derangements associated

with obesity and improves glycemic control in mouse

models of type 2

diabetes. This or related compounds warrant further investigation as novel

adjunctive therapies for type 2 diabetes in man.

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